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At 24 hours the plasma amounts of sildenafil ended up however roughly 200 ng/mL, compared to approximately 5 ng/mL when sildenafil was dosed alone. This is often in step with ritonavir's marked effects with a wide number of P450 substrates. VIAGRA experienced no effect on ritonavir pharmacokinetics [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIO